Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen.RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus exerting an inhibitory effect on the Raf-MEK-Erk pathway.RKIP has been identified as a metastasis supp
Comparative transcriptomic analysis delineates adaptation strategies of Rana kukunoris toward cold stress on the Qinghai-Tibet Plateau
Abstract Background Cold hardiness is fundamental for amphibians to survive during the extremely cold winter on the Qinghai-Tibet plateau.Exploring the gene regulation mechanism of freezing-tolerant Rana kukunoris could help us to understand how the frogs survive in winter.Results Transcriptome of liver and muscle of R.kukunoris collected in hibern
Bilayer Local Search Enhanced Particle Swarm Optimization for the Capacitated Vehicle Routing Problem
The classical capacitated vehicle routing problem (CVRP) is a very popular combinatorial optimization problem in the field of logistics and supply chain management.Although CVRP has drawn interests of many researchers, no standard way has been established yet to obtain best known solutions for all the different problem sets.We propose an efficient
Intent to migrate among nursing students in Uganda: Measures of the brain drain in the next generation of health professionals
Abstract Background There is significant concern about the worldwide migration of nursing professionals from low-income countries to rich ones, as nurses are lured to fill the large number of vacancies in upper-income countries.This study explores the views of nursing students in Uganda to assess their views on practice options and their intentions